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M94A3182.TXT
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1994-10-25
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Document 3182
DOCN M94A3182
TI HTLV-I infection in healthy blood donors in Russia.
DT 9412
AU Parfanovich M; Zuntova Yu; Vlshemirsky O; Plvovarova I; D.I. Ivanovsky
Institute of Virology, Moscow, Russia.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):134 (abstract no. PA0157). Unique
Identifier : AIDSLINE ICA10/94369393
AB 1176 sera from the patients with the different forms of haemoblastosis,
blood donors, people from Chernobyl-region, patients with haemophilia
were studied in 1993. The presence of antibodies to HTLV-I in sera was
determined by indirect ELISA on the basis of natural viral antigen and
was confirmed by Western blot Du Pont and in ELISA-test on the basis of
synthetic peptides. 15 sera with the positive results were revealed. The
positive results were confirmed by Western blot in 4 cases from blood
donors (3 sera contained the antibodies to p19 gag protein; 1--to p24
gag protein, and 4--to gp46 env protein). 3 sera were negative and 8
sera were uncertain (they contained antibodies only to gag
proteins--p19, p24, p26, p28, p53 in different combinations). So the
percentage of seropositive sera makes up approximately 0.34%. It is
necessary to note that carefully selected sera were used for the studies
that probably explains rather high percentage of infection.
DE *Blood Donors Blotting, Western Comparative Study Enzyme-Linked
Immunosorbent Assay Gene Products, gag/IMMUNOLOGY
Hemophilia/COMPLICATIONS Human HTLV-I Antibodies/BLOOD HTLV-I
Infections/BLOOD/DIAGNOSIS/*EPIDEMIOLOGY Prevalence
Russia/EPIDEMIOLOGY Ukraine MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).